Options
ac4CSNPer
A real-time analysis module to assess the impact of genetic variants on database collection
The following options are available:
- The input: Standard VCF file
- Species: Species selected for analysis. (default: Homo sapiens (human))
- Modification Type: Modification type selected for analysis. (default: ac4C)
- Association Level: The association level (AL) between genetic variant and RNA modification site, AL ranges from 0 to 1 with 1 indicating the greatest impact of the variant on modification status. Users can tune this value. (default: 0.4)
- Prediction Mode: Two prediction modes are available. Experimentally validated ac4C datasets mode: the uploaded SNPs will be analyzed to assess their impact on the collected ac4C datasets. This will report predicted ac4C-loss variants in high and medium confidence levels, respectively. Transcriptome-wide prediction mode: the ac4CSNPer predicts the impact of reference- and mutated-sequences (altered by the uploaded SNPs) around transcriptome-wide guanosines, reporting ac4C-loss and ac4C-gain variants in the low confidence level.
*Note: Please see example VCF input provided.
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